Biologic Response to Carbonated Hydroxyapatite Associated with Orthopedic Device: Experimental Study in a Rabbit Model
Jebahi Samira, Saoudi Mongi, Badraoui Riadh, Rebai Tarek, Oudadesse Hassane, Ellouz Zoubaier, Keskese Hassib, Feki Abdelfattah El, Feki Hafed El,
소속 상세정보
( Jebahi Samira )
Tunisia Medicine Faculty of Sfax Laboratory of Orthopaedic and Traumatology
( Saoudi Mongi )
Tunisia Sciences Faculty of Sfax Department of Life Sciences Animal Ecophysiology Laboratory
( Badraoui Riadh )
Tunisia Medicine Faculty of Sfax Laboratory of Histology
( Rebai Tarek )
Tunisia Medicine Faculty of Sfax Laboratory of Histology
( Oudadesse Hassane )
France University of Rennes
( Ellouz Zoubaier )
Tunisia Medicine Faculty of Sfax Laboratory of Orthopaedic and Traumatology
( Keskese Hassib )
Tunisia Medicine Faculty of Sfax Laboratory of Orthopaedic and Traumatology
( Feki Abdelfattah El )
Tunisia Sciences Faculty of Sfax Department of Life Sciences Animal Ecophysiology Laboratory
( Feki Hafed El )
Tunisia Sciences Faculty of Sfax Laboratory of Science of Materials and Environment
KMID : 0357920120460010048
Abstract
Background: Carbonated hydroxyapatite (CHA) and related calcium phosphates have been studied for many years as implant materials due to their similarity with the mineral phase of bone. The main limitation of CHA ceramics as well as other bioactive materials is that they have poor mechanical proprieties. It is thought that the mechanical device can cause an increase in metabolic activity and bone healing. In this study we investigated the reactivity and tissue behaviour of implanted CHA biomaterial reinforced by mini external fixator.
Methods: The evaluation of biomaterial biocompatibility and osteogenesis was performed on a rabbit model over a period of 6 weeks by radiological, histological and scanning electron microscopy (SEM) coupled with energy dispersive X-ray SEM-energy-dispersive X-ray (EDX) analysis.
Results: While rabbits treated with CHA exhibited more bone formation, and fibrous tissue was observed when empty bone defects were observed. EDX analysis detected little calcium and phosphorus on the surface of the bone that was not implanted, while high content of calcium (62.7%) and phosphorus (38%) was found on the interface bone cement.
Conclusions: Bone repairing showed that the mini external fixator stimulated the ossification which was pushed when grafted by CHA. This effect may play an important role in the prevention of implant loosening.
키워드
Biocompatible materials; Testing bone substitute
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