Evaluation of Urine Cytology in Urothelial Carcinoma Patients: A Comparison of CellprepPlus® Liquid-Based Cytology and Conventional Smear
손승명, 구지혜, 최송이, 이호창, 이용문, 송형근, Hwang Hae-Kyung, 한혜숙, 윤석중, 김원재, 김은중, 이옥준,
소속 상세정보
손승명 ( Son Seung-Myoung )
Chungbuk National University College of Medicine Department of Pathology
구지혜 ( Koo Ji-Hae )
Chungbuk National University College of Medicine Department of Pathology
최송이 ( Choi Song-Yi )
Chungbuk National University College of Medicine Department of Pathology
이호창 ( Lee Ho-Chang )
Chungbuk National University College of Medicine Department of Pathology
이용문 ( Lee Yong-Moon )
Chungbuk National University College of Medicine Department of Pathology
송형근 ( Song Hyung-Geun )
Chungbuk National University College of Medicine Department of Pathology
( Hwang Hae-Kyung )
Chungbuk National University College of Medicine Department of Pathology
한혜숙 ( Han Hye-Suk )
Chungbuk National University College of Medicine Department of Internal Medicine
윤석중 ( Yun Seok-Joong )
Chungbuk National University College of Medicine Department of Urology
김원재 ( Kim Wun-Jae )
Chungbuk National University College of Medicine Department of Urology
김은중 ( Kim Eun-Joong )
Juseong University Department of Clinical Laboratory Science
이옥준 ( Lee Ok-Jun )
Chungbuk National University College of Medicine Department of Pathology
KMID : 0357920120460010068
Abstract
Background: Urine cytology is an important test in the screening of urothlelial neoplasms. The conventional smear (CS) method of testing urine samples has a low sensitivity, approximately 50% result accuracy for detecting urothelial carcinomas, while liquid-based cytology (LBC) has much improved diagnostic accuracy, sensitivity, and specificity. The aim of this study was to compare the morphologic features and diagnostic efficacy of CellprepPlus® LBC with those of CS for urine cytology.
Methods: A total of 713 cases of urine specimens collected from November 2009 to September 2010 were included. All specimens were divided equally for the preparation of CellprepPlus ® LBC and CS for each case.
Results: CellprepPlus® revealed more cellularity, a cleaner background and better cytomorphologic features, but it showed a less intact architectural pattern compared to that of CS. Of the 88 histologically confirmed cases, the diagnostic sensitivity for CellprepPlus® was 50% and higher than the 37.5% for CS. The specificity of both preparations was 100%.
Conclusions: The CellprepPlus® showed an improved quality of slides and provided better diagnostic accuracy, thus CellprepPlus® could be a first-line screening tool in urinary tract cytology.
키워드
Carcinoma; urothelial; Urine; cytology; Urinary bladder neoplasms
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