Metaplastic Thymoma: Report of 4 Cases
강구현, 윤나라, 한정호, 김영은, 김태성, 김관민,
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강구현 ( Kang Gu-Hyun )
Sungkyunkwan University School of Medicine Department of Pathology
윤나라 ( Yoon Na-Ra )
Sungkyunkwan University School of Medicine Department of Pathology
한정호 ( Han Joung-Ho )
Sungkyunkwan University School of Medicine Department of Pathology
김영은 ( Kim Young-Eun )
Sungkyunkwan University School of Medicine Department of Pathology
김태성 ( Kim Tae-Sung )
Sungkyunkwan University School of Medicine Department of Radiology
김관민 ( Kim Kwhan-Mien )
Sungkyunkwan University School of Medicine Department of Thoracic Surgery
KMID : 0357920120460010092
Abstract
Metaplastic thymoma (MT), accepted in the World Health Organization 2004 scheme, is a circumscribed tumor of the thymus exhibiting biphasic morphology. We herein describe the clinicopathologic features of four MTs and the differential diagnoses of this unusual tumor. There were three women and one man with mean age of 49.5 years. The patients were found to have mediastinal masses, and underwent surgical excision. One exhibited symptoms of myasthenia gravis, and the serum titer for anti-acetylcholine receptor antibody was positive. Grossly, the tumors were encapsulated, and showed vaguely multinodular, solid, tan-white to yellow cut surfaces. Histologically, they comprised epithelial islands intertwining with bundles of delicate spindle cells. The patients remained well after surgical excision at 5-55 months. Because of the distinctive histological appearance and benign clinical course, MT should be distinguished from other more aggressive mediastinal neoplasms displaying biphasic feature.
키워드
Mediastinal neoplasms; Thymoma; Carcinosarcoma; Metaplasia; Myasthenia gravis
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