Significance of Electron Dense Deposits in Patients with Minimal Change Nephrotic Syndrome
김세윤, 이상수, 김명욱, 이재민, 강석정, 김용진, 박용훈,
소속 상세정보
김세윤 ( Kim Sae-Yoon )
Yeungnam University College of Medicine Department of Pediatrics
이상수 ( Lee Sang-Su )
Yeungnam University College of Medicine Department of Pediatrics
김명욱 ( Kim Myung-Uk )
Yeungnam University College of Medicine Department of Pediatrics
이재민 ( Lee Jae-Min )
Yeungnam University College of Medicine Department of Pediatrics
강석정 ( Kang Seok-Jeong )
Yeungnam University College of Medicine Department of Pediatrics
김용진 ( Kim Yong-Jin )
Yeungnam University College of Medicine Department of Pathology
박용훈 ( Park Yong-Hoon )
Yeungnam University College of Medicine Department of Pediatrics
KMID : 0357920120460020137
Abstract
Background : Minimal change nephritic syndrome (MCNS) is characterized by a lack of obvious abnormalities on light microscopy, but its electron microscopic findings include the negative immunofluorescence findings and the diffuse effacement of the epithelial cell foot processes. Rarely the presence of electron dense deposits (EDDs) has been reported, but its clinical significance remains obscure.
Methods : Eleven patients with MCNS who had the EDD deposited were enrolled in the current study. We compared the clinical characteristics, laboratory results and response to steroid treatment between the two group: the EDD group (n=11; the male-to-female ratio, 8:3) and the non-EDD group (n=13, 8:5).
Results : There were no significant differences in most of the laboratory results or response to steroid treatment between the two groups. The frequency of relapses per year was significantly higher in the EDD group (1.1±0.7 times vs. 0.5±0.6 times; p=0.023). These EDDs were found in the mesangium or paramesangium. With no respect to the characteristics of EDDs, our results showed that they did not cause poor treatment outcomes except for the annual frequency of relapse.
Conclusions : Further large-scale studies are warrented to determine the immunologic and prognostic significance of EDDs in patients with MCNS.
키워드
Minimal change; Nephrotic syndrome; Electron dense deposit
원문 및 링크아웃 정보
등재저널 정보