Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
민수기, 고영호, Park Yun-Woong, 김효정, 서진원, 박혜림, 조성진, 김인선,
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민수기 ( Min Soo-Kee )
Hallym University Sacred Heart Hospital Department of Pathology
고영호 ( Koh Young-Ho )
Hallym University Ilsong Institute of Life Science
( Park Yun-Woong )
Hallym University Ilsong Institute of Life Science
김효정 ( Kim Hyo-Jung )
Hallym University College of Medicine Department of Hemato-Oncology
서진원 ( Seo Jin-Won )
Hallym University College of Medicine Department of Pathology
박혜림 ( Park Hye-Rim )
Hallym University College of Medicine Department of Pathology
조성진 ( Cho Seong-Jin )
Hallym University College of Medicine Department of Pathology
김인선 ( Kim In-Sun )
Korea University College of Medicine Department of Pathology
KMID : 0357920120460020142
Abstract
Background : It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.
Methods : We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.
Results : The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05).
Conclusions : HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
키워드
Acetylation; Deacetylation; Histone deacetylase inhibitors; Lymphoma
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