Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma
유지인, 한원철, 윤기중, 문형배, 오경재, 채수천,
소속 상세정보
유지인 ( Yu Ji-In )
Wonkwang University School of Medicine Department of Pathology
한원철 ( Han Weon-Cheol )
Wonkwang University School of Medicine Department of Pathology
윤기중 ( Yun Ki-Jung )
Wonkwang University School of Medicine Department of Pathology
문형배 ( Moon Hyung-Bae )
Wonkwang University School of Medicine Department of Pathology
오경재 ( Oh Gyung-Jae )
Wonkwang University Medical School Department of Preventive Medicine
채수천 ( Chae Soo-Cheon )
Wonkwang University School of Medicine Department of Pathology
KMID : 0357920120460020162
Abstract
Background : Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.
Methods : Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.
Results : There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).
Conclusions : Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.
키워드
IL31; Haplotypes; Polymorphism; Asthma; Immunoglobulin E
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