Expression of Human Papillomavirus-Related Proteins and Its Clinical Implication in Tonsillar Squamous Cell Carcinoma
송준선, 김민식, Park Joon-Wook, 이연수, 강창석,
소속 상세정보
송준선 ( Song Joon-Seon )
Catholic University College of Medicine Department of Hospital Pathology
김민식 ( Kim Min-Sik )
Catholic University School of Medicine Department of Olaryngology-Head and Neck Surgery
( Park Joon-Wook )
Catholic University College of Medicine Department of Hospital Pathology
이연수 ( Lee Youn-Soo )
Catholic University School of Medicine Department of Hospital Pathology
강창석 ( Kang Chang-Suk )
Catholic University College of Medicine Department of Hospital Pathology
KMID : 0357920120460020177
Abstract
Background : Human papillomavirus (HPV) is known to cause of oropharyngeal squamous cell carcinoma (SqCC). HPV positive SqCCs overexpress p16 and are associated with better survival. Several markers of cell cycles and apoptosis have been reported as a prognostic value. We examined the prognostic value of HPV status, p16, cyclin D1, and Bcl-2 in patients with tonsillar SqCC.
Methods : Tissue microarrays were constructed in 56 cases of tonsillar SqCC for which we performed an immunohistochemistry and an in situ hybridization (ISH) of the HPV.
Results : Of the 56 cases, 31 (55.3%) were positive for p16 and 20 (35.7%) were positive for HPV ISH. The expressions of p16, cyclin D1, and Bcl-2 were not correlated with the clinicopathologic variables including smoking status, differentiation and pT- and pN-stages. The HPV ISH positive group showed a better overall survival than the HPV negative group (p=0.04), and the p16 positive group showed a better disease free survival (DFS) than the negative group (p=0.016). Cox regression analysis showed that only p16 positivity was an independent prognostic factor for DFS (p=0.03; hazard ratio, 10.1).
Conclusions : Our results indicate that both p16 expression and HPV status are useful indicators for risk stratification in patients with tonsillar SqCC.
키워드
Human papillomavirus; Palatine tonsil; Carcinoma; squamous cell carcinoma; p16; Bcl-2; Cyclin D1
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