Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript
류한석, 허일영, 고재수, 진성호, 강혜진, 조수연,
소속 상세정보
류한석 ( Ryu Han-Suk )
Chung-Ang University College of Medicine Department of Pathology
허일영 ( Heo Il-Yeong )
Korea Institute of Radiological & Medical Sciences Department of Pathology
고재수 ( Koh Jae-Soo )
Korea Institute of Radiological & Medical Sciences Department of Pathology
진성호 ( Jin Sung-Ho )
Korea Institute of Radiological & Medical Sciences Korea Cancer Center Hospital Department of Surgery
강혜진 ( Kang Hye-Jin )
Korea Institute of Radiological & Medical Sciences Korea Cancer Center Hospital Department of Internal Medicine
조수연 ( Cho Soo-Youn )
Korea Institute of Radiological & Medical Sciences Department of Pathology
KMID : 0357920120460020187
Abstract
Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.
키워드
Synovial sarcoma; Mesentery; Spindle cell sarcoma; Immunohistochemistry; Reverse transcriptase polymerase chain reaction
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