Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report
최유미, 이경열, 장민혜, 설혜실, 김성원, 박소연,
소속 상세정보
최유미 ( Choi Yoo-Mi )
Seoul National University College of Medicine Department of Pathology
이경열 ( Lee Kyoung-Yul )
Seoul National University College of Medicine Department of Pathology
장민혜 ( Jang Min-Hye )
Seoul National University College of Medicine Department of Pathology
설혜실 ( Seol Hye-Sil )
Korea Institute of Radiological & Medical Sciences Department of Pathology
김성원 ( Kim Sung-Won )
Seoul National University Bundang Hospital Department of Surgery
박소연 ( Park So-Yeon )
Seoul National University Bundang Hospital Department of Pathology
KMID : 0357920120460020205
Abstract
Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
키워드
Invasive carcinoma; Phyllodes tumor; Breast; Cribriform
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