Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
한지영, 김규호, 김루시아, 최석진, 박인서, 김준미, 주영채, 윤상민,
소속 상세정보
한지영 ( Han Jee-Young )
Inha University College of Medicine Department of Pathology
김규호 ( Kim Kyu-Ho )
Inha University College of Medicine Department of Pathology
김루시아 ( Kim Lucia )
Inha University College of Medicine Department of Pathology
최석진 ( Choi Suk-Jin )
Inha University College of Medicine Department of Pathology
박인서 ( Park In-Suh )
Inha University College of Medicine Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University College of Medicine Department of Pathology
주영채 ( Chu Young-Chae )
Inha University College of Medicine Department of Pathology
윤상민 ( Yoon Sang-Min )
Inha University College of Medicine Department of Urology
KMID : 0357920120460020210
Abstract
Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of primary clear cell adenocarcinoma of the female urethra with its cytological findings. A 54-year-old woman presented with a painless gross hematuria lasting 3 months. On vaginal sonography, there was a sausage-like, elongated mass in the urethra, measuring 3.8× 4.3 cm. The voided urine cytology revealed small clusters of rounded or papillary cells. The necrotic debris and inflammatory cells were present within some clusters of tumor cells. These tumor cells were enlarged and had abundant clear or granular cytoplasm with cytoplasmic vacuoles. The nucleus was granular and contained vesicular chromatin with prominent nucleoli. The hobnail cells and hyaline globules were also present as in a histologic section. The histologic findings were compatible with clear cell adenocarcinoma. The tumor showed distinctive cytological features. Cytologically, however, it is necessary to make a differential diagnosis from other adenocarcinoma or high-grade urothelial carcinoma.
키워드
Adenocarcinoma; clear cell; Urethra; Cytology
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