Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases
최영화, 김혜령, 최해영, 황대현, 최기영, 정진행, 박소연, 이혜승, 백진호, 박효진,
소속 상세정보
최영화 ( Choi Young-Hwa )
Seoul National University College of Medicine Department of Pathology
김혜령 ( Kim Hae-Ryoung )
Seoul National University Bundang Hospital Department of Pathology
최해영 ( Choi Hai-Young )
Seoul National University College of Medicine Department of Pathology
황대현 ( Hwang Dae-Hyun )
Seoul National University College of Medicine Department of Pathology
최기영 ( Choe Ghee-Young )
Seoul National University College of Medicine Department of Pathology
정진행 ( Chung Jin-Haeng )
Seoul National University Bundang Hospital Department of Pathology
박소연 ( Park So-Yeon )
Seoul National University Bundang Hospital Department of Pathology
이혜승 ( Lee Hye-Seung )
Seoul National University Bundang Hospital Department of Pathology
백진호 ( Paik Jin-Ho )
Seoul National University College of Medicine Department of Pathology
박효진 ( Park Hyo-Jin )
Seoul National University College of Medicine Department of Pathology
KMID : 0357920120460020215
Abstract
Villoglandular adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma with a more favorable prognosis compared to conventional adenocarcinomas. Although the tumors are usually recognized on colposcopic examination due to the mainly exophytic growth pattern, they may be underdiagnosed as benign lesions by cytology because of their minimal cytologic atypia. We report the liquid-based cytology (LBC) findings of three histologically confirmed VGAs which we have recently identified. They were characterized by hypercellular smears on low-power examination with smooth-bordered three-dimensional papillary fragments. The nuclei were relatively uniform with irregular nuclear membranes. Nucleoli were small but distinct and macronucleoli were also seen. The abnormal architectural patterns such as papillary structures and nuclear overlapping and nuclear hyperchromasia are important clues to the diagnosis of VGA. In addition, nuclear membrane irregularity and prominent nucleoli can be recognized on LBC specimens, further facilitating its diagnosis.
키워드
Villoglandular adenocarcinoma; Uterine cervical neoplasms; Liquid-based cytology
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