Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors
안수민, 이재준, 하상윤, 성창옥, 김진국, 한정호,
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안수민 ( Ahn Soo-Min )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
이재준 ( Lee Jae-Jun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
하상윤 ( Ha Sang-Yun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
성창옥 ( Sung Chang-Ohk )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
김진국 ( Kim Jhin-Gook )
Sungkyunkwan University School of Medicine Department of Thoracic Surgery
한정호 ( Han Joung-Ho )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
KMID : 0357920120460030221
Abstract
Background : Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.
Methods : We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.
Results : It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing’s syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.
Conclusions : In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.
키워드
Thymus gland; Carcinoid tumor; Carcinoma; neuroendocrine
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