Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
박은수, 김영은, 박철근, Yao Takashi, Kushima RyoJi, 김경미,
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박은수 ( Park Eun-Su )
Catholic University School of Medicine Department of Hospital Pathology
김영은 ( Kim Young-Eun )
Sungkyunkwan University School of Medicine Department of Pathology
박철근 ( Park Cheol-Keun )
Sungkyunkwan University School of Medicine Department of Pathology
( Yao Takashi )
Juntendo University Department of Human Pathology
( Kushima RyoJi )
National Cancer Center Hospital Clinical Laboratory Division
김경미 ( Kim Kyoung-Mee )
Catholic University School of Medicine Department of Hospital Pathology
KMID : 0357920120460030287
Abstract
Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.
키워드
Stomach neoplasms; Fundic gland; Chief cells; gastric; Cell differentiation; Pepsinogen A
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