Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication
유택균, 김경민, 노상재, 배준상, 장규윤, 정명자, 문우성, 강명재, 이동근, 박호성,
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유택균 ( You Tack-Kune )
Chonbuk National University Medical School Department of Pathology
김경민 ( Kim Kyoung-Min )
Chonbuk National University Medical School Department of Pathology
노상재 ( Noh Sang-Jae )
Chonbuk National University Medical School Department of Pathology
배준상 ( Bae Jun-Sang )
Chonbuk National University Medical School Department of Pathology
장규윤 ( Jang Kyu-Yun )
Chonbuk National University Medical School Department of Pathology
정명자 ( Chung Myoung-Ja )
Chonbuk National University Medical School Department of Pathology
문우성 ( Moon Woo-Sung )
Chonbuk National University Medical School Department of Pathology
강명재 ( Kang Myoung-Jae )
Chonbuk National University Medical School Department of Pathology
이동근 ( Lee Dong-Geun )
Chonbuk National University Medical School Department of Pathology
박호성 ( Park Ho-Sung )
Chonbuk National University Medical School Department of Pathology
KMID : 0357920120460040331
Abstract
Background: E-cadherin, cortactin, and matrix metalloproteinase (MMP)-9 have roles in tumor development or progression, but their expression has not been fully investigated in pseudoepitheliomatous hyperplasia (PEH) and squamous cell carcinoma (SCC) of the head and neck.
Methods: We evaluated the immunohistochemical expression of E-cadherin, cortactin, and MMP-9 in 29 cases of PEH and 97 cases of SCC. Additionally, we evaluated their relationship with clinicopathologic factors and prognostic implications in SCC.
Results: Thirty-five cases of SCC showed reduced expression of E-cadherin, whereas none of the PEH did. A total of 20 cases and 11 cases of SCC were immunoreactive for cortactin and MMP-9, respectively, whereas none of the PEH did. In SCC, reduced expression of E-cadherin was correlated with cortactin expression and invasion depth. Cortactin expression was correlated with differentiation, T classification, and recurrence and/or metastasis. MMP-9 expression was correlated with invasion depth. Cortactin expression was correlated with poor overall survival and relapse-free survival and it was an independent prognostic factor.
Conclusions: The reduced expression of E-cadherin and the expression of cortactin may be helpful for the differential diagnosis of PEH and SCC. Furthermore, cortactin expression in association with reduced E-cadherin expression is correlated with poor prognosis in SCC.
키워드
Carcinoma; squamous cell; Pseudoepitheliomatous hyperplasia; Cadherins; Cortactin; Matrix metalloproteinase 9; Head and neck neoplasms
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