The Histologic Cut-off Point for Adjacent and Remote Non-neoplastic Liver Parenchyma of Hepatocellular Carcinoma in Chronic Hepatitis B Patients
정혜연, 김수희, Jing Jin, 곽재문, 한철주, 장자준, 이경분,
소속 상세정보
정혜연 ( Jung Hae-Yoen )
Seoul National University College of Medicine Department of Pathology
김수희 ( Kim Soo-Hee )
National Cancer Center Department of Pathology
( Jing Jin )
Seoul National University College of Medicine Department of Pathology
곽재문 ( Gwak Jae-Moon )
Seoul National University College of Medicine Department of Pathology
한철주 ( Han Chul-Ju )
Korea Institute of Radiological and Medical Science Korea Cancer Center Hospital Department of Internal Medicine
장자준 ( Jang Ja-June )
Seoul National University College of Medicine Department of Pathology
이경분 ( Lee Kyoung-Bun )
Seoul National University College of Medicine Department of Pathology
KMID : 0357920120460040349
Abstract
Background: The molecular profile of peritumoral non-neoplastic liver parenchyma (PNLP) has recently been suggested as predictive factor of early and late recurrence of hepatocellular carcinoma (HCC). However, there is no definite cut-off point for tumor-free PNLP in terms of either histological or molecular changes. Therefore, our aim is to determine the numerical cut-off point for separating adjacent PNLP and remote PNLP in histopathologic perspective.
Methods: Peritumoral tissues from 20 resected HCC patients were sampled from 0 to 40 mm distance from the tumor border (divided into 5-mm columns). Histopathologic parameters such as necroinflammatory activity, fibrosis, bile ductular reaction, hepatic venulitis, peliosis, and steatosis were compared between each column.
Results: The morphologic changes just adjacent to the tumor were notably severe and faded with distance. The parenchyma within 10 mm of the tumor showed significantly severe inflammation, fibrosis, peliosis and hepatic venulitis compared with those from farther areas. The histopathologic changes of the parenchyma became stable beyond 20 mm.
Conclusions: Results of this study revealed that the parenchyma within 10 mm distance from the tumor, or adjacent PNLP, has histopathologic changes that are directly affected by the tumor, and the parenchyma beyond 20 mm as the remote PNLP without tumor effect.
키워드
Nonneoplastic liver parenchyma; Carcinoma; hepatocellular; Hepatitis B; chronic
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