Comparison of Diagnostic Cytomorphology of Atypical Squamous Cells in Liquid-Based Preparations and Conventional Smears
이중달, 오영하, 이성옥, Kim Jong-Yull,
소속 상세정보
이중달 ( Lee Jung-Dal )
한양대학교 의과대학 병리학교실
오영하 ( Oh Young-Ha )
Hanyang University College of Medicine Department of Pathology
이성옥 ( Lee Seong-Ok )
Seoul Song Do Hospital Department of Pathology
( Kim Jong-Yull )
Cell and Tech Bio Corporation
KMID : 0357920120460040365
Abstract
Background: The aims of this study were to compare the cytomorphologic features diagnostic of atypical squamous cells (ASC) in liquid-based preparations (LBPs) and conventional Pap (CP) smears and to cytomorphologically assess the performance of the Cell Scan 1500TM in cervical cytology practice.
Methods: Cervicovaginal smears were obtained from 938 women. Two smears were obtained simultaneously from each individual, one for an LBP and the other for a CP smear; the smears were independently examined. ASC was diagnosed in 24 patients, and their samples were cytomorphologically and semiquantitatively analyzed.
Results: A total of 24 of the 938 women (2.6%) were diagnosed with ASC by one or both methods. Results from LBPs and CP smears were in agreement in 13 of 24 cases of ASC diagnosis (absolute direct agreement, 54.2%; k<0.20; p-value from chi-square test=0.085). Diagnostic features of ASC in the LBPs included squamous cell atypia and atypical squamous metaplasia.
Conclusions: The cellular features diagnostic of ASC present in one preparation can manifest themselves differently in the other. Changes in individual cells, particularly nuclear changes, are the most reliable features for diagnosing ASC. The Cell Scan 1500TM processor is more effective at detecting ASC than are CP smears.
키워드
Atypical squamous cells; Cytomorphologic comparison; Liquid-based preparation; Conventional smear
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