Primary Thymic Mucinous Adenocarcinoma: A Case Report
쟘시드 압둘 가파, 용석중, 권우철, 박일환, 정순희,
소속 상세정보
쟘시드 압둘 가파 ( Jamshid Abdul-Ghafar )
Yonsei University Wonju College of Medicine Department of Internal Medicine
용석중 ( Yong Suk-Joong )
Yonsei University Wonju College of Medicine Department of Internal Medicine
권우철 ( Kwon Woo-Cheol )
Yonsei University Wonju College of Medicine Department of Radiology
박일환 ( Park Il-Hwan )
Yonsei University Wonju College of Medicine Department of Thoracic Surgery
정순희 ( Jung Soon-Hee )
Yonsei University Wonju College of Medicine Department of Pathology
KMID : 0357920120460040377
Abstract
Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.
키워드
Thymus gland; Adenocarcinoma; mucinous; Mediastinal cyst; Immunohistochemistry
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