DPC4 Expression in the Small Intestinal Adenocarcinomas
이선재, 유은실, 배영경, 장기택, 김준미, 배한익, 홍승모, 윤길석,
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이선재 ( Lee Sun-Jae )
Kyungpook National University School of Medicine Department of Pathology
유은실 ( Yu Eun-Sil )
University of Ulsan College of Medicine Department of Pathology
배영경 ( Bae Young-Kyung )
Yeungnam University College of Medicine Department of Pathology
장기택 ( Jang Kee-Taek )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University College of Medicine Department of Pathology
배한익 ( Bae Han-Ik )
Kyungpook National University School of Medicine Department of Pathology
홍승모 ( Hong Seung-Mo )
University of Ulsan College of Medicine Department of Pathology
윤길석 ( Yoon Ghil-Suk )
Kyungpook National University School of Medicine Department of Pathology
KMID : 0357920120460050415
Abstract
Background : Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis.
Methods : We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology.
Results : Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival.
Conclusions : The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.
키워드
Smad4/DPC4; Adenocarcinoma; Intestine; small; Immunohistochemistry
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