ERG Immunohistochemistry and Clinicopathologic Characteristics in Korean Prostate Adenocarcinoma Patients
Suh Ja-Hee, Park Jeong-Whan, 이철, 문경철,
소속 상세정보
( Suh Ja-Hee )
Seoul National University College of Medicine Department of Pathology
( Park Jeong-Whan )
Seoul National University College of Medicine Department of Pathology
이철 ( Lee Cheol )
Seoul National University College of Medicine Department of Pathology
문경철 ( Moon Kyung-Chul )
Seoul National University College of Medicine Department of Pathology
KMID : 0357920120460050423
Abstract
Background : Transmembrane protease serine 2-ETS related gene (TMPRSS2-ERG) gene fusion, the most common genetic alternation in prostate cancer, is associated with protein expression of the oncogene ERG. Recently, an immunohistochemical staining method using an anti-ERG antibody was shown to have a strong correlation with altered ERG protein expression.
Methods : We analyzed a total of 303 radical prostatectomy specimens (obtained from Korean prostate cancer cases) using a constructed tissue microarray and ERG immunohistochemical staining. Thereafter, we evaluated the association between ERG expression and clinicopathological factors.
Results : The ERG-positive rate was 24.4% (74/303) and significantly higher ERG expression was observed in the subgroup with a lower Gleason score (p=0.004). Analysis of the histologic pattern of prostate adenocarcinomas revealed that tumors with discrete glandular units (Gleason pattern 3) displayed higher frequency of ERG expression (p=0.016). The ERG-positive rate was lower than that found (approximately 50%) in studies involving western populations. Other factors including age, tumor volume, initial protein-specific antigen level, a pathological stage and margin status were not significantly related with the ERG expression.
Conclusions : ERG immunohistochemical staining is significantly higher in tumors with well-formed glands and is associated with a lower Gleason score.
키워드
Prostate neoplasms; ERG; Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보