Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication
김요나, 최지은, 배준상, 장규윤, 정명자, 문우성, 강명재, 이동근, 박호성,
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김요나 ( Kim Yo-Na )
Chonbuk National University Medical School Department of Pathology
최지은 ( Choi Ji-Eun )
Chonbuk National University Medical School Department of Pathology
배준상 ( Bae Jun-Sang )
Chonbuk National University Medical School Department of Pathology
장규윤 ( Jang Kyu-Yun )
Chonbuk National University Medical School Department of Pathology
정명자 ( Chung Myoung-Ja )
Chonbuk National University Medical School Department of Pathology
문우성 ( Moon Woo-Sung )
Chonbuk National University Medical School Department of Pathology
강명재 ( Kang Myoung-Jae )
Chonbuk National University Medical School Department of Pathology
이동근 ( Lee Dong-Geun )
Chonbuk National University Medical School Department of Pathology
박호성 ( Park Ho-Sung )
Chonbuk National University Medical School Department of Pathology
KMID : 0357920120460050454
Abstract
Background : Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.
Methods : The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.
Results : Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.
Conclusions : Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.
키워드
Colorectal neoplasms; Cortactin; Focal adhesion protein-tyrosine kinases; Immunohistochemistry
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