Expression of CHOP in Squamous Tumor of the Uterine Cervix
Chu Hyun-Hee, 배준상, 김경민, 박호성, 조동휴, 장규윤, 문우성, 강명재, 이동근, 정명자,
소속 상세정보
( Chu Hyun-Hee )
Chonbuk National University Medical School Department of Pathology
배준상 ( Bae Jun-Sang )
Chonbuk National University Medical School Department of Pathology
김경민 ( Kim Kyoung-Min )
Chonbuk National University Medical School Department of Pathology
박호성 ( Park Ho-Sung )
Chonbuk National University Medical School Department of Pathology
조동휴 ( Cho Dong-Hyu )
Chonbuk National University Medical School Department of Obstetrics and Gynecology
장규윤 ( Jang Kyu-Yun )
Chonbuk National University Medical School Department of Pathology
문우성 ( Moon Woo-Sung )
Chonbuk National University Medical School Department of Pathology
강명재 ( Kang Myoung-Jae )
Chonbuk National University Medical School Department of Pathology
이동근 ( Lee Dong-Geun )
Chonbuk National University Medical School Department of Pathology
정명자 ( Chung Myoung-Ja )
Chonbuk National University Medical School Department of Pathology
KMID : 0357920120460050463
Abstract
Background : High-risk human papillomavirus (HR-HPV) infection and abnormal p53 expression are closely involved in carcinogenesis of squamous cell carcinoma (SqCC) of uterine cervix. Recent studies have suggested that virus-induced endoplasmic reticulum (ER) stress modulates various cell survival and cell death signaling pathways. The C/EBP homologous protein (CHOP) is associated with ER stress-mediated apoptosis and is also involved in carcinogenesis of several human cancers. We hypothesized that CHOP is involved in the carcinogenesis of uterine cervical cancer in association with HR-HPV and/or p53.
Methods : Immunohistochemistry was used to analyze CHOP and p53 protein expression of tissue sections from 191 patients with invasive cancer or preinvasive lesions of the uterine cervix (61 cases of SqCC, 66 cases of cervical intraepithelial neoplasia [CIN] III, and 64 cases of CIN I).
Results : CHOP was expressed in 59.4% of CIN I, 48.5% of CIN III, and 70.5% of SqCC cases. It was also significantly more frequent in invasive SqCC than in preinvasive lesions (p=0.042). Moreover, CHOP expression significantly correlated with HR-HPV infection and p53 expression (p=0.009 and p=0.038, respectively).
Conclusions : Our results suggest that CHOP is involved in the carcinogenesis of the uterine cervix SqCC via association with HR-HPV and p53.
키워드
Transcription factor CHOP; Uterine cervical neoplasms; DNA probes; HPV; Tumor suppressor protein p53
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