Cytologic Features of Giant Cell Ependymoma: A Case Report and Review of the Literature
고명주, 윤선옥, 전혜민, 정현주, 홍순원, 김세훈,
소속 상세정보
고명주 ( Koh Myoung-Ju )
Yonsei University College of Medicine Department of Pathology
윤선옥 ( Yoon Sun-Och )
Yonsei University College of Medicine Department of Pathology
전혜민 ( Jeon Hyae-Min )
Yonsei University College of Medicine Department of Pathology
정현주 ( Jeong Hyeon-Joo )
Yonsei University College of Medicine Department of Pathology
홍순원 ( Hong Soon-Won )
Yonsei University College of Medicine Department of Pathology
김세훈 ( Kim Se-Hoon )
Yonsei University College of Medicine Department of Pathology
KMID : 0357920120460050507
Abstract
Here, we present a case of anaplastic giant cell ependymoma (GCE) occurring in a 15-year-old woman. Squash smear slides for intraoperative frozen section diagnosis revealed oval to round cell clusters with a papillary structure in a fibrillary background. This was occasionally accompanied by the presence of bizarre pleomorphic giant cells with hyperchromatic nuclei and prominent intranuclear inclusions. These intranuclear inclusions were a key clue to diagnosis of ependymoma. Histologic analysis revealed features of a high-grade tumor with perivascular pseudorosettes and bizarre pleomorphic giant cells, which established the diagnosis of GCE. We performed a review of literatures about the cytologic features of GCE, including our case, thus proposing that intraoperative frozen diagnosis of GCE would be established by squash smear preparations featuring the mitosis and necrosis, as well as the high cellularity, and the presence of giant cells showing hyperchromatic nuclei with eosinophilic cytoplasm and intranuclear inclusions/pseudoinclusions.
키워드
Ependymoma; Intranuclear inclusion bodies; Giant cells
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