Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
강영란, 정원용, 이현주, 이은정, 김애리, 김백희,
소속 상세정보
강영란 ( Kang Young-Ran )
Korea University College of Medicine Department of Pathology
정원용 ( Jung Woon-Yong )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
이현주 ( Lee Hyun-Joo )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pathology
이은정 ( Lee Eun-Jung )
Korea University College of Medicine Department of Pathology
김애리 ( Kim Ae-Ree )
Korea University College of Medicine Department of Pathology
김백희 ( Kim Baek-Hui )
Korea University College of Medicine Department of Pathology
KMID : 0357920120460060523
Abstract
Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics.
Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed.
Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012).
Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.
키워드
Stomach; Adenocarcinoma; DBC1 protein; human; SIRT1 protein; human
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