Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers
김경빈, 박원영, 김지연, 설미영, 신동훈, 박도윤, 이창훈, 이정희, 최경운,
소속 상세정보
김경빈 ( Kim Kyung-Bin )
Pusan National University Hospital Department of Pathology
박원영 ( Park Won-Young )
Pusan National University Hospital Department of Pathology
김지연 ( Kim Jee-Yeon )
Pusan National University School of Medicine Department of Pathology
설미영 ( Sol Mee-Young )
Pusan National University School of Medicine Department of Pathology
신동훈 ( Shin Dong-Hun )
Pusan National University School of Medicine Department of Pathology
박도윤 ( Park Do-Youn )
Pusan National University School of Medicine Department of Pathology
이창훈 ( Lee Chang-Hun )
Pusan National University School of Medicine Department of Pathology
이정희 ( Lee Jeong-Hee )
Pusan National University Yangsan Hospital Department of Pathology
최경운 ( Choi Kyung-Un )
Pusan National University School of Medicine Department of Pathology
KMID : 0357920120460060532
Abstract
Background: Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis.
Methods: Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC).
Results: CA IX expression was significantly associated with an endometrioid and mucinous histology, nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers.
Conclusions: The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.
키워드
Ovarian epithelial cancer; Carbonic anhydrase IX; GLUT-1; Vascular endothelial growth factor A
원문 및 링크아웃 정보
등재저널 정보