Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung
최희승, 설혜실, 허일영, 정창원, 조수연, 박선후, 고재수, 이승숙,
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최희승 ( Choi Hee-Seung )
Korea Institute of Radiological & Medical Sciences Department of Pathology
설혜실 ( Seol Hye-Sil )
Korea Institute of Radiological & Medical Sciences Department of Pathology
허일영 ( Heo Il-Yeong )
Korea Institute of Radiological & Medical Sciences Department of Pathology
정창원 ( Jung Chang-Won )
Korea Institute of Radiological & Medical Sciences Department of Pathology
조수연 ( Cho Soo-Youn )
Korea Institute of Radiological & Medical Sciences Department of Pathology
박선후 ( Park Sun-Hoo )
Korea Institute of Radiological & Medical Sciences Department of Pathology
고재수 ( Koh Jae-Soo )
Korea Institute of Radiological & Medical Sciences Department of Pathology
이승숙 ( Lee Seung-Sook )
Korea Institute of Radiological & Medical Sciences Department of Pathology
KMID : 0357920120460060576
Abstract
Background: Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.
Methods: We reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.
Results: The tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.
Conclusions: PC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.
키워드
Pleomorphic carcinoma; Lung; Cytology
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