Cervical Lymphadenopathy Mimicking Angioimmunoblastic T-Cell Lymphoma after Dapsone-Induced Hypersensitivity Syndrome
임민영, 홍준식, 박현수, 정동해, 안정열, 박상희, 박진희, 김연수, 이재훈,
소속 상세정보
임민영 ( Rim Min-Young )
Gachon University Gil Hospital Department of Internal Medicine
홍준식 ( Hong Jun-Shik )
Gachon University Gil Hospital Department of Internal Medicine
박현수 ( Park Hyeon-Su )
Gachon University Gil Hospital Department of Internal Medicine
정동해 ( Chung Dong-Hae )
Gachon University Gil Hospital Department of Pathology
안정열 ( Ahn Jeong-Yeal )
Gachon University Gil Hospital Department of Laboratory Medicine
박상희 ( Park Sang-Hui )
Ewha Womans University School of Medicine Department of Pathology
박진희 ( Park Jinny )
Gachon University Gil Hospital Department of Internal Medicine
김연수 ( Kim Yun-Soo )
Gachon University Gil Hospital Department of Internal Medicine
이재훈 ( Lee Jae-Hoon )
Gachon University Gil Hospital Department of Internal Medicine
KMID : 0357920120460060606
Abstract
A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma. However, it was assumed that the cervical lymphadenopathy was a clinical manifestation of a systemic hypersensitivity reaction because her clinical course was reminiscent of dapsone-induced hypersensitivity syndrome. A liver biopsy revealed drug-induced hepatitis with no evidence of lymphomatous involvement. Intravenous glucocorticoid was immediately initiated and her symptoms and clinical disease dramatically improved. The authors present an unusual case of cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma as an adverse reaction to dapsone.
키워드
Pseudolymphoma; Dapsone therapy
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