Morphologic Analysis of Pulmonary Neuroendocrine Tumors
Lee Seung-Seok, 강명희, 하승연, 안준석, 노미숙, 하창원, 한정호,
소속 상세정보
( Lee Seung-Seok )
Gachon University School of Medicine Department of Pathology
강명희 ( Kang Myung-Hee )
Gachon University School of Medicine Department of Pathology
하승연 ( Ha Seung-Yeon )
Gachon University Gil Medical Center Department of Pathology
안준석 ( An Jung-Suk )
Gachon University Gil Medical Center Department of Pathology
노미숙 ( Roh Mee-Sook )
Dong-A University College of Medicine Department of Pathology
하창원 ( Ha Chang-Won )
Cheju Halla General Hospital Department of Pathology
한정호 ( Han Jung-Ho )
Sungkyunkwan University School of Medicine Department of Pathology
KMID : 0357920130470010016
Abstract
Background: Few studies on how to diagnose pulmonary neuroendocrine tumors through morphometric analysis have been reported. In this study, we measured and analyzed the characteristic parameters of pulmonary neuroendocrine tumors using an image analyzer to aid in diagnosis. Methods: Sixteen cases of typical carcinoid tumor, 5 cases of atypical carcinoid tumor, 15 cases of small cell carcinoma, and 51 cases of large cell neuroendocrine carcinoma were analyzed. Using an image analyzer, we measured the nuclear area, perimeter, and the major and minor axes. Results: The mean nuclear area was 0.318±0.101 μm2 in typical carcinoid tumors, 0.326±0.119 μm2 in atypical carcinoid tumors, 0.314±0.107 μm2 in small cell carcinomas, and 0.446±0.145 μm2 in large cell neuroendocrine carcinomas. The mean nuclear circumference was 2.268±0.600 μm in typical carcinoid tumors, 2.408±0.680 μm in atypical carcinoid tumors, 2.158±0.438 μm in small cell carcinomas, and 3.247±1.276 μm in large cell neuroendocrine carcinomas. All parameters were useful in distinguishing large cell neuroendocrine carcinoma from other tumors (p=0.001) and in particular, nuclear circumference was the most effective (p=0.001). Conclusions: Pulmonary neuroendocrine tumors showed nuclear morphology differences by subtype. Therefore, evaluation of quantitative nuclear parameters improves the accuracy and reliability of diagnosis.
키워드
Typical carcinoid tumor; Atypical carcinoid tumor; Carcinoma; small cell; Carcinoma; large cell; Carcinoma; neuroendocrine; Pulmonary neuroendocrine tumor
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