Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
정민정, 송준선, 김상윤, 남순열, 노종렬, 최승호, 김성배, 조경자,
소속 상세정보
정민정 ( Jung Min-Jung )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
송준선 ( Song Joon-Seon )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
김상윤 ( Kim Sang-Yoon )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
남순열 ( Nam Soon-Yuhl )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
노종렬 ( Roh Jong-Lyel )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
최승호 ( Choi Seung-Ho )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
김성배 ( Kim Sung-Bae )
University of Ulsan College of Medicine Asan Medical Center Department of Medical Oncology
조경자 ( Cho Kyung-Ja )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
KMID : 0357920130470010036
Abstract
Background: A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features. Methods: Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor. Results: Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive. Conclusions: MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.
키워드
Salivary gland neoplasms; Carcinoma; acinar cell; in situ hybridization; fluorescence; ETV6-NTRK3 fusion protein; human
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