Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma
김효진, 유설봉, Sun Ping-Li, Jin Yan, 전상훈, 이춘택, 정진행,
소속 상세정보
김효진 ( Kim Hyo-Jin )
Seoul National University College of Medicine Department of Pathology
유설봉 ( Yoo Seol-Bong )
Seoul National University College of Medicine Department of Pathology
( Sun Ping-Li )
Seoul National University College of Medicine Department of Pathology
( Jin Yan )
Seoul National University College of Medicine Department of Pathology
전상훈 ( Jheon Sang-Hoon )
Seoul National University Bundang Hospital Department of Thoracic Surgery
이춘택 ( Lee Choon-Taek )
Seoul National University Bundang Hospital Department of Internal Medicine
정진행 ( Chung Jin-Haeng )
Seoul National University College of Medicine Department of Pathology
KMID : 0357920130470010044
Abstract
Background: Epithelial-mesenchymal transition (EMT) is an important step in the invasion and progression of cancer and in the development of chemoresistance by cancer cells. Methods: To address the clinical significance of the EMT pathway in lung adenocarcinoma and the association of the pathway with histological subtype, we examined 193 surgically resected lung adenocarcinoma samples for the expression of representative EMT-related proteins (E-cadherin, β-catenin, and vimentin) by immunohistochemistry. Histological subtypes were classified according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results for EMT-related protein expression were analyzed for correlation with clinicopathological features and with survival. Results: The loss of Ecadherin expression and aberrant β-catenin expression were significantly associated with larger tumor size, pleural invasion, lymphatic/vascular invasion, and advanced pathological stage (p< 0.05). The alteration of the E-cadherin/β?catenin complex was least frequently observed in the lepidic-predominant group, but these associations were not statistically significant. In the multivariate analysis, altered E-cadherin/β-catenin complex expression was found to be an independent poor prognostic factor (p=0.017; hazard ratio, 1.926; 95% confidence interval, 1.119 to 3.314). Conclusions: The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma.
키워드
Epithelial-mesenchymal transition; Cadherin/catenin complex; Immunohistochemistry; Lung neoplasms
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