Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases
성우정, 신형찬, 김민경, 김미진,
소속 상세정보
성우정 ( Sung Woo-Jung )
Yeungnam University College of Medicine Department of Pathology
신형찬 ( Shin Hyeong-Chan )
Yeungnam University College of Medicine Department of Pathology
김민경 ( Kim Min-Kyung )
Catholic University of Daegu School of Medicine Department of Pathology
김미진 ( Kim Mi-Jin )
Yeungnam University College of Medicine Department of Pathology
KMID : 0357920130470010067
Abstract
Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.
키워드
Epithelioid trophoblastic tumor; Gestational trophoblastic disease
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