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Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group

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½ÉÈ¿¼· ( Shim Hyo-Sup ) 
Yonsei University College of Medicine Department of Pathology

Á¤ÁøÇà ( Chung Jin-Haeng ) 
Seoul National University Bundang Hospital Department of Pathology
±è·ç½Ã¾Æ ( Kim Lucia ) 
Inha University College of Medicine Department of Pathology
Àå¼±Èñ ( Chang Sun-Hee ) 
Inje University Ilsan Paik Hospital Department of Pathology
±è¿Ï¼· ( Kim Wan-Seop ) 
Konkuk University College of Medicine Department of Pathology
À̰DZ¹ ( Lee Geon-Kook ) 
National Cancer Center Department of Pathology
Á¤¼øÈñ ( Jung Soon-Hee ) 
Yonsei University Wonju College of Medicine Department of Pathology
Àå¼¼Áø ( Jang Se-Jin ) 
University of Ulsan College of Medicine Asan Medical Center Department of Pathology

Abstract


Mutations of the epidermal growth factor receptor (EGFR) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutated EGFR. Rapid and accurate EGFR mutation testing is essential for patient selection and establishing targeted therapies with EGFR TKIs. Thus, a standard set of guideline recommendations for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of guideline recommendations for EGFR mutation testing that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

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Mutation; Receptor; epidermal growth factor; Guideline

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