Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis
이미지, 김성배, 이상욱, 노종렬, 최승호, 남순열, 김상윤, 조경자,
소속 상세정보
이미지 ( Lee Mi-Ji )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
김성배 ( Kim Sung-Bae )
University of Ulsan College of Medicine Asan Medical Center Department of Medical Oncology
이상욱 ( Lee Sang-Wook )
University of Ulsan College of Medicine Asan Medical Center Department of Radiation Oncology
노종렬 ( Roh Jong-Lyel )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
최승호 ( Choi Seung-Ho )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
남순열 ( Nam Soon-Yuhl )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
김상윤 ( Kim Sang-Yoon )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
조경자 ( Cho Kyung-Ja )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
KMID : 0357920130470020148
Abstract
Background: Human papillomavirus (HPV)-related tonsillar squamous cell carcinoma (TSCC) has recently been characterized as a distinct subset with a favorable prognosis. The prevalence and clinicopathologic significance of HPV-related TSCC in Koreans are not well known. Methods: HPV in situ hybridization (ISH) accompanied by p53, p16, pRb, and cyclin D1 immunohistochemical staining were performed on 89 resection cases of TSCC from 2000 through 2010. Results: HPV was detected by ISH in 59 of 89 cases (66.3%). HPV-positive TSCCs were more common in younger ages (p=0.005), and tumor sizes were smaller in the HPV-positive compared to the HPVnegative group (p=0.040). Positive HPV staining was significantly correlated with p16 expression (p<0.001), pRb inactivation (p=0.003), and cyclin D1 down-regulation (p<0.001) but not with p53 expression (p=0.334). Seventeen cases that showed p16-immunopositivity with HPV-negativity by ISH were retested by HPV typing; HPV DNA was not detected in all cases. There was no significant difference between HPV-positive and HPV-negative patients either in the disease-specific survival (DSS, p=0.857) or overall survival (p=0.910). Furthermore, pRb-inactivated cases showed better DSS (p=0.023), and p53-positive cases showed worse DSS (p=0.001). Conclusions: Although high HPV prevalence was noted, it was not correlated with histopathologic findings or survival benefit. In addition to p53 expression, pRb inactivation along with p16 overexpression and down-regulation of cyclin D1 are thought to be important pathogenetic steps for developing TSCCs.
키워드
Human papillomavirus; Tonsillar neoplasm; Carcinoma; squamous cell; Cyclin-dependent kinase inhibitor p16; Tumor suppressor protein p53
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