Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
배고은, 윤나라, 박하영, 하상윤, 조준훈, 이윤경, 김경미, 박철근,
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배고은 ( Bae Go-Eun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
윤나라 ( Yoon Na-Ra )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
박하영 ( Park Ha-Young )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
하상윤 ( Ha Sang-Yun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
조준훈 ( Cho Jun-Hun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
이윤경 ( Lee Yun-Kyung )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
김경미 ( Kim Kyoung-Mee )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
박철근 ( Park Cheol-Keun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
KMID : 0357920130470020163
Abstract
Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 μm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
키워드
Malakoplakia; Colon; Kidney transplantation
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