Histopathologic Predictors of Lymph Node Metastasis and Prognosis in Tonsillar Squamous Cell Carcinoma
이동진, 권미정, 남은숙, 권지현, 김진환, 노영수, 신형식, 조성진,
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이동진 ( Lee Dong-Jin )
Hallym University Kangnam Sacred Heart Hospital Department of Otorhinolaryngology-Head and Neck Surgery
권미정 ( Kwon Mi-Jung )
Hallym University Sacred Heart Hospital Department of Pathology
남은숙 ( Nam Eun-Sook )
Hallym University Kangdong Sacred Heart Hospital Department of Pathology
권지현 ( Kwon Ji-Hyun )
Hallym University Kangdong Sacred Heart Hospital Department of Pathology
김진환 ( Kim Jin-Hwan )
Hallym University Kangdong Sacred Heart Hospital Department of Otorhinolaryngology-Head and Neck Surgery
노영수 ( Rho Young-Soo )
Hallym University Kangdong Sacred Heart Hospital Department of Otorhinolaryngology-Head and Neck Surgery
신형식 ( Shin Hyung-Sik )
Hallym University Kangdong Sacred Heart Hospital Department of Pathology
조성진 ( Cho Seong-Jin )
Hallym University Kangdong Sacred Heart Hospital Department of Pathology
KMID : 0357920130470030203
Abstract
Background: Risk factors for lymph node metastasis in tonsillar squamous cell carcinoma (TSCC) need to be established to determine the degree of surgery required to achieve high curative rates. However, little is known currently about the histopathological features predicting prognosis, specifically in TSCC. Methods: This study included 53 patients who underwent surgical resection with neck dissection. Clinicopathological factors investigated included age, gender, alcohol use, tobacco consumption, tumor stage, adjacent structure involvement, cell differentiation, squamous dysplasia, in situ carcinoma associated with primary invasive cancer, carcinoma in situ skip lesions, necrosis, invasive front, depth of invasion, and lymphatic, muscle, or perineural invasion. Results: Contralateral cervical metastasis was associated with higher T stages and soft palate invasion. Lymphatic and muscle invasion were associated with ipsilateral cervical metastasis. Advanced T stage, invasion to the base of tongue, and skip lesions were associated with decreased disease-free survival. Advanced T stage and skip lesions were associated with worse overall survival. Conclusions: Advanced T stage and soft palate invasion may predict a high risk of contralateral nodal metastasis. T stage and skip lesion are worse prognostic factors in TSCC and should be commented in pathology reports.
키워드
Palatine tonsil; Carcinoma; squamous cell; Prognosis; Lymph nodes; Neoplasm metastasis
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