Proposal for a Standardized Pathology Report of Gastroenteropancreatic Neuroendocrine Tumors: Prognostic Significance of Pathological Parameters
Korean Society of Pathologists, 조미연, 손진희, 진소영, 김현기, 정은선, 김미정, 김경미, 김우호, 김준미, 강윤경, 최준혁, 강대영, 김윤화, 최은희,
소속 상세정보
( Korean Society of Pathologists )
소속확인중
조미연 ( Cho Mee-Yon )
Yonsei University Wonju College of Medicirne Wonju Severance Christian Hospital Department of Pathology
손진희 ( Sohn Jin-Hee )
Sungkyunkwan University School of Medicine Kangbuk Samsung Medical Center Department of Pathology
진소영 ( Jin So-Young )
Soonchunhyang University Hospital Department of Pathology
김현기 ( Kim Hyun-Ki )
Yonsei University College of Medicine Severance Hospital Department of Pathology
정은선 ( Jung Eun-Sun )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Pathology
김미정 ( Kim Mi-Jung )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
김경미 ( Kim Kyoung-Mee )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
김우호 ( Kim Woo-Ho )
Seoul National University Hospital Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University Hospital Department of Pathology
강윤경 ( Kang Yun-Kyung )
Inje University Seoul Paik Hospital Department of Pathology
최준혁 ( Choi Joon-Hyuk )
Yeungnam University Medical Center Department of Pathology
강대영 ( Kang Dae-Young )
Chungnam National University Hospital Department of Pathology
김윤화 ( Kim Youn-Wha )
Kyung hee University Medical Center Department of Pathology
최은희 ( Choi Eun-Hee )
Yonsei University Wonju College of Medicine
KMID : 0357920130470030227
Abstract
Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.
키워드
Neuroendocrine tumors; Digestive system; Pathology; Staging; Grading; Prognosis
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