Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
하승연, Ahn Jung-Suk, 노미숙, 한정호, 이재준, 이보인, Yim Jun,
소속 상세정보
하승연 ( Ha Seung-Yeon )
Gachon University Gil Medical Center Department of Pathology
( Ahn Jung-Suk )
Gachon University Gil Medical Center Department of Pathology
노미숙 ( Roh Mee-Sook )
Dong-A University College of Medicine Department of Pathology
한정호 ( Han Joung-Ho )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
이재준 ( Lee Jae-Jun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
이보인 ( Lee Bo-In )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
( Yim Jun )
Gachon University Graduate School of Medicine Department of Preventive Medicine
KMID : 0357920130470030252
Abstract
Background: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. Methods: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. Results: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. Conclusions: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
키워드
Adenocarcinoma; Lung; Anaplastic lymphoma kinase; Carcinoma; non-small-cell lung; Cytology
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