Myxoid Liposarcoma with Cartilaginous Differentiation: A Case Study with Cytogenetical Analysis
김현철, Hwangbo Won, 안상정, Kim Suh-Jin, 김인선, 김철환,
소속 상세정보
김현철 ( Kim Hyun-Chul )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
( Hwangbo Won )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
안상정 ( Ahn Sang-Jeong )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
( Kim Suh-Jin )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
김인선 ( Kim In-Sun )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
김철환 ( Kim Chul-Hwan )
Korea University College of Medicine Korea University Anam Hospital Department of Pathology
KMID : 0357920130470030284
Abstract
Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.
키워드
Liposarcoma; myxoid; Cartilaginous differentiation; Cartilage; Heterologous component; TLS/CHOP fusion transcript
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