Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation
김욱연, 고영신, 황태숙, 한혜승, 임소덕, 김완섭, 오서영,
소속 상세정보
김욱연 ( Kim Wook-Youn )
Konkuk University School of Medicine Department of Pathology
고영신 ( Ko Young-Sin )
Konkuk University School of Medicine Department of Pathology
황태숙 ( Hwang Tae-Sook )
Konkuk University School of Medicine Department of Pathology
한혜승 ( Han Hye-Seung )
Konkuk University School of Medicine Department of Pathology
임소덕 ( Lim So-Dug )
Konkuk University School of Medicine Department of Pathology
김완섭 ( Kim Wan-Seop )
Konkuk University School of Medicine Department of Pathology
오서영 ( Oh Seo-Young )
Konkuk University Medical Center Department of Pathology
KMID : 0357920130470030293
Abstract
Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
키워드
Thyroid gland; Carcinoma; papillary; BRAF V600E; BRAF K601E
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