SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
정원경, 홍광대, 정원용, 이은정, 신봉경, 김한겸, 김애리, 김백희,
소속 상세정보
정원경 ( Jung Won-Kyung )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
홍광대 ( Hong Kwang-Dae )
Korea University College of Medicine Korea University Guro Hospital Department of Surgery
정원용 ( Jung Woon-Yong )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
이은정 ( Lee Eun-Jung )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
신봉경 ( Shin Bong-Kyung )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
김한겸 ( Kim Han-Kyeom )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
김애리 ( Kim Ae-Ree )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
김백희 ( Kim Baek-Hui )
Korea University College of Medicine Korea University Guro Hospital Department of Pathology
KMID : 0357920130470040332
Abstract
Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of β-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of β-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), β-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with β-catenin and survivin rather than p53.
키워드
Colon; Adenocarcinoma; SIRT1; DBC1; Beta catenin
원문 및 링크아웃 정보
등재저널 정보