The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development
장태정, 박정배, 이종임,
소속 상세정보
장태정 ( Jang Tae-Jung )
Dongguk University College of Medicine Department of Pathology
박정배 ( Park Jeong-Bae )
Dongguk University College of Medicine Department of Internal Medicine
이종임 ( Lee Jong-Im )
Dongguk University College of Medicine Department of Pathology
KMID : 0357920130470040340
Abstract
Background: The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC. Methods: We performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon. Results: CD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth. Conclusions: The present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.
키워드
Neprilysin; Antigens; CD15; Colorectal neoplasms
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