Cytological Findings of the Micropapillary Variant of Urothelial Carcinoma: A Comparison with Typical High-Grade Urothelial Carcinoma
김규호, 최창환, 한지영, 김루시아, 최석진, 박인서, 김준미, 주영채,
소속 상세정보
김규호 ( Kim Kyu-Ho )
Inha University Hospital Department of Pathology
최창환 ( Choi Chang-Hwan )
Inha University Hospital Department of Pathology
한지영 ( Han Jee-Young )
Inha University Hospital Department of Pathology
김루시아 ( Kim Lucia )
Inha University Hospital Department of Pathology
최석진 ( Choi Suk-Jin )
Inha University Hospital Department of Pathology
박인서 ( Park In-Suh )
Inha University Hospital Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University Hospital Department of Pathology
주영채 ( Chu Young-Chae )
Inha University Hospital Department of Pathology
KMID : 0357920130470040365
Abstract
Background: Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC). Methods: The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli. Results: Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli. Conclusions: The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei. Than that of HGUC these features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.
키워드
Micropapillary; Urothelial carcinoma; Cytology; Urine
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