Fine Needle Aspiration Cytology of Parathyroid Lesions
허일영, 박선후, Jung Chang-Won, 고재수, 이승숙, 설혜실, 최희승, 조수연,
소속 상세정보
허일영 ( Heo Il-Yeong )
Korea Cancer Center Hospital Department of Pathology
박선후 ( Park Sun-Hoo )
Korea Cancer Center Hospital Department of Pathology
( Jung Chang-Won )
Korea Cancer Center Hospital Department of Pathology
고재수 ( Koh Jae-Soo )
Korea Cancer Center Hospital Department of Pathology
이승숙 ( Lee Seung-Sook )
Korea Cancer Center Hospital Department of Pathology
설혜실 ( Seol Hye-Sil )
Korea Cancer Center Hospital Department of Pathology
최희승 ( Choi Hee-Seung )
Korea Cancer Center Hospital Department of Pathology
조수연 ( Cho Soo-Youn )
Korea Cancer Center Hospital Department of Pathology
KMID : 0357920130470050466
Abstract
Background: There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria. Methods: We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011. Results: Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information. Conclusions: FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.
키워드
Parathyroid lesions; Biopsy; fine-needle; Cytology
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