Prognostic Significance of Absolute Lymphocyte Count/Absolute Monocyte Count Ratio at Diagnosis in Patients with Multiple Myeloma
신수진, 노진, 김미성, 정민정, 고영화, 박찬식, 윤덕현, Suh Cheol-Won, 박찬정, 지현숙, 허주령,
소속 상세정보
신수진 ( Shin Su-Jin )
University of Ulsan College of Medicine Department of Pathology
노진 ( Roh Jin )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
김미성 ( Kim Mi-Sung )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
정민정 ( Jung Min-Jung )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
고영화 ( Koh Young-Wha )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
박찬식 ( Park Chan-Sik )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
윤덕현 ( Yoon Dok-Hyun )
University of Ulsan College of Medicine Department of Oncology
( Suh Cheol-Won )
University of Ulsan College of Medicine Department of Oncology
박찬정 ( Park Chan-Jeong )
University of Ulsan College of Medicine Asan Medical Center Department of Laboratory Medicine
지현숙 ( Chi Hyun-Sook )
University of Ulsan College of Medicine Asan Medical Center Department of Laboratory Medicine
허주령 ( Huh Joo-Ryung )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
KMID : 0357920130470060525
Abstract
Background: Absolute lymphocyte count (ALC) in peripheral blood has recently been reported to be an independent prognostic factor in multiple myeloma (MM). Previous studies indicated that the absolute monocyte count (AMC) in peripheral blood reflects the state of the tumor microenvironment in lymphomas. Neither the utility of the AMC nor its relationship with ALC has been studied in MM.
Methods: The prognostic value of ALC, AMC, and the ALC/AMC ratio at the time of diagnosis was retrospectively examined in 189 patients with MM.
Results: On univariate analysis, low ALC (<1,400 cells/μL), high AMC (≥490 cells/μL), and low ALC/AMC ratio (<2.9) were correlated with worse overall survival (OS) (p=.002, p=.038, and p=.001, respectively). On multivariate analysis, the ALC/AMC ratio was an independent prognostic factor (p=.047), whereas ALC and AMC were no longer statistical significant. Low ALC, high AMC, and low ALC/AMC ratio were associated with poor prognostic factors such as high International Staging System stage, plasmablastic morphology, hypoalbuminemia, and high β2-microglobulin.
Conclusions: Univariate analysis demonstrated that changes in ALC, AMC, and the ALC/AMC ratio are associated with patient survival in MM. Multivariate analysis showed that, of these factors, the ALC/AMC ratio was an independent prognostic factor for OS.
키워드
Multiple myeloma; Lymphocytes; Monocytes; Lymphocyte/monocyte ratio; Prognosis
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