Microtubule-Associated Protein Tau, α-Tubulin and βIII-Tubulin Expression in Breast Cancer
임소영, 유창영, 정지한, 전예원, 서영진, 이연수, 최현주,
소속 상세정보
임소영 ( Im So-Young )
Catholic University College of Medicine St. Vincent’s Hospital Department of Hospital Pathology
유창영 ( Yoo Chang-Young )
Catholic University College of Medicine St. Vincent’s Hospital Department of Hospital Pathology
정지한 ( Jung Ji-Han )
Catholic University College of Medicine St. Vincent’s Hospital Department of Hospital Pathology
전예원 ( Jeon Ye-Won )
Catholic University College of Medicine St. Vincent’s Hospital Departments of Surgery
서영진 ( Suh Young-Jin )
Catholic University College of Medicine St. Vincent’s Hospital Departments of Surgery
이연수 ( Lee Youn-Soo )
Catholic University Seoul St. Mary’s Hospital Department of Hospital Pathology
최현주 ( Choi Hyun-Joo )
Catholic University College of Medicine St. Vincent’s Hospital Department of Hospital Pathology
KMID : 0357920130470060534
Abstract
Background: The microtubule-associated protein Tau binds to both inner and outer surfaces of microtubules, leading to tubulin assembly and microtubule stabilization. The aim of this study was to evaluate the significance of Tau, α-tubulin, and βIII-tubulin expression in breast carcinoma and to assess their relationships with disease progression in the context of taxane treatment.
Methods: Immunohistochemical expressions of Tau, α-tubulin, and βIII-tubulin were assessed in 183 breast cancer cases. Expression was correlated with clinicopathologic parameters, disease progression and overall survival.
Results: Tau expression was correlated with lymph node metastasis and estrogen receptor (ER) positivity (p=.003 and p<.001, respectively). Loss of α-tubulin was significantly correlated with distant metastasis (p=.034). Loss of βIII-tubulin was correlated with lymph node metastasis and ER positivity (p=.004 and p<.001, respectively). In taxanetreated cases, Tau expression and loss of α-tubulin and βIII-tubulin expression were related to disease progression (p=.001, p=.028, and p=.030, respectively). Tau expression was associated with a worse survival rate in taxane-treated patients (p=.049).
Conclusions: Tau expression and loss of α-tubulin and βIII-tubulin expression were correlated with aggressive behavior in taxane- treated breast cancer. Further evaluation of Tau, α-tubulin and βIII-tubulin may be useful in predicting clinical behavior and seeking therapeutic measures in taxane-based chemotherapy for breast cancer.
키워드
Tau proteins; Tubulin; Taxoids; Breast neoplasms
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