Usual Interstitial Pneumonia with Lung Cancer: Clinicopathological Analysis of 43 Cases
송대현, 최인호, 하상윤, 한강민, 이재준, 홍민의, 전경만, 정만표, 김진국, 한정호,
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송대현 ( Song Dae-Hyun )
Sungkyunkwan University School of Medicine Department of Pathology
최인호 ( Choi In-Ho )
Sungkyunkwan University School of Medicine Department of Pathology
하상윤 ( Ha Sang-Yun )
Sungkyunkwan University School of Medicine Department of Pathology
한강민 ( Han Kang-Min )
Sungkyunkwan University School of Medicine Department of Pathology
이재준 ( Lee Jae-Jun )
Sungkyunkwan University School of Medicine Department of Pathology
홍민의 ( Hong Min-Eui )
Sungkyunkwan University School of Medicine Department of Pathology
전경만 ( Jeon Kyeong-Man )
Sungkyunkwan University School of Medicine Department of Internal Medicine
정만표 ( Chung Man-Pyo )
Sungkyunkwan University School of Medicine Department of Internal Medicine
김진국 ( Kim Jhin-Gook )
Sungkyunkwan University School of Medicine Department of Thoracic Surgery
한정호 ( Han Joung-Ho )
Sungkyunkwan University School of Medicine Department of Pathology
KMID : 0357920140480010010
Abstract
Background: Previous studies have suggested an association between usual interstitial pneumonia (UIP) and lung cancer (Ca). However, clinical and histological information is not enough to determine such an association, due to the low incidence and short survival time of patients with both conditions.
Methods: We retrospectively reviewed the clinical and histological records of Ca patients with UIP between January 1999 and August 2013 at the Samsung Medical Center, Seoul, Korea. We found 43 patients who had Ca with UIP (UIP-Ca). Previously reported data of eighty-four patients with UIP-only were included as a comparison group.
Results: Smoking is related to poor prognosis in patients with UIP-Ca, and the number of patients with a high smoking index of more than 30 pack-years significantly increased in UIP-Ca patients compared with UIPonly patients. There is no significant prognostic differentiation between UIP-Ca patients and UIPonly patients. Microscopically, UIP-Ca patients showed characteristically heterogeneous histological patterns and degrees of differentiation. There were many foci of squamous metaplasia or dysplasia at the peripheral area of squamous cell carcinomas.
Conclusions: We report 43 cases of UIP-Ca. Our results suggest that smoking is related to cancer occurrence in UIP patients and poor prognosis in UIP-Ca patients.
키워드
Idiopathic pulmonary fibrosis; Lung neoplasms; Metaplasia; Smoking; Etiology; Survival
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