Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas
김나래, 강명희, 이순표, 김현철, 안준석, 정동해, 하승연, 조현이,
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김나래 ( Kim Na-Rae )
Gachon University Gil Hospital Department of Pathology
강명희 ( Kang Myung-Hee )
Gachon University School of Medicine Department of Pathology
이순표 ( Lee Soon-Pyo )
Gachon University Gil Medical Center Department of Obstetrics and Gynecology
김현철 ( Kim Hyun-Chul )
Gachon University Gil Medical Center Department of Pathology
안준석 ( An Jung-Suk )
Gachon University Gil Medical Center Department of Pathology
정동해 ( Chung Dong-Hae )
Gachon University Gil Medical Center Department of Pathology
하승연 ( Ha Seung-Yeon )
Gachon University Gil Medical Center Department of Pathology
조현이 ( Cho Hyun-Yee )
Gachon University Gil Medical Center Department of Pathology
KMID : 0357920140480010043
Abstract
Background: Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 and 18. However, the roles and contributions of other uncommon and rare genotypes remain uncertain.
Methods: HPV genotypes were retrospectively assessed using an HPV DNA chip that can specify up to 32 HPV genotypes. We arbitrarily regarded genotypes accounting for less than 6% of the total as uncommon and rare genotypes.
Results: A total of 3,164 HPV-positive cases were enrolled. In groups 2A, 2B, 3, and unclassified HPV genotypes, 2.4% of cases with uncommon HPV genotypes (68, 26, 34, 53, 66, 69, 70, 73, 40, 42, 43, 44, 54, 55, 61, 62, 6, and 11) showed high grade squamous intraepithelial lesions and ICs. There were no HPV32- and 57-infected cases.
Conclusions: We found that the uncommon and rare HPV genotypes may provide incremental etiologic contributions in cervical carcinogenesis, especially HPV68, 70, and 53. Further studies on these uncommon and rare HPV genotypes will be of importance in establishing the significance of genotypes in different regions, especially in planning a strategy for further vaccine development as well as follow-up on the effectiveness of the currently used vaccines.
키워드
Human papillomavirus; Cervix uteri; Carcinogenesis; Genotype
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