Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
Oh Woo-Jin, 이영섭, 조의주, 박경신, 이연수, 정찬권, 배자성, 이소희, 김민희, 임동준,
소속 상세정보
( Oh Woo-Jin )
Catholic University College of Medicine Department of Hospital Pathology
이영섭 ( Lee Young-Sub )
Catholic University College of Medicine Department of Hospital Pathology
조의주 ( Cho Ui-Ju )
Catholic University College of Medicine Department of Hospital Pathology
박경신 ( Park Gyeong-Sin )
Catholic University Seoul St. Mary’s Hospital Department of Hospital Pathology
이연수 ( Lee Youn-Soo )
Catholic University College of Medicine Department of Hospital Pathology
정찬권 ( Jung Chan-Kwon )
Catholic University College of Medicine Department of Hospital Pathology
배자성 ( Bae Ja-Seong )
Catholic University College of Medicine Department of Surgery
이소희 ( Lee So-Hee )
Catholic University College of Medicine Department of Surgery
김민희 ( Kim Min-Hee )
Catholic University School of Medicine Department of Internal Medicine
임동준 ( Lim Dong-Jun )
Catholic University College of Medicine Department of Internal Medicine
KMID : 0357920140480030201
Abstract
Background: The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF).
Methods: We retrospectively selected and reviewed the clinicopathologic features and presence of the BRAF mutation in 203 cases of classic PTC, 149 cases of classic PTC with TCF, and 95 cases of TCVPTCs, which were defined as PTCs having <10%, 10-50%, and ≥50% tall cells, respectively.
Results: TCVPTCs and classic PTCs with TCF did not vary significantly in clinicopathologic characteristics such as pathologic (p) T stage, extrathyroidal extension, pN stage, lateral lymph node metastasis, or BRAF mutations; however, these features differed significantly in TCVPTCs and classic PTCs with TCF in comparison to classic PTCs. Similar results were obtained in a subanalysis of patients with microcarcinomas (≤1.0 cm in size).
Conclusions: Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs.
키워드
Thyroid neoplasms; Histologic types; Classification; Tall cell features
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