Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical and BRAF Analysis
박지혜, 권형주, 박정수, 홍순원,
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박지혜 ( Park Ji-Hye )
Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
권형주 ( Kwon Hyeong-Ju )
Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
박정수 ( Park Cheong-Soo )
Yonsei University College of Medicine Department of Surgery
홍순원 ( Hong Soon-Won )
Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
KMID : 0357920140480030234
Abstract
This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.
키워드
Thyroid cancer; anaplastic; Young adult; Proto-oncogene proteins B-raf; Immunohistochemistry
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