The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
김규호, 김루시아, 최석진, 한지영, 김준미, 주영채, 김영모, 박인서, 임주한,
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김규호 ( Kim Kyu-Ho )
Inha University School of Medicine Inha University Hospital Department of Pathology
김루시아 ( Kim Lucia )
Inha University School of Medicine Inha University Hospital Department of Pathology
최석진 ( Choi Suk-Jin )
Inha University School of Medicine Inha University Hospital Department of Pathology
한지영 ( Han Jee-Young )
Inha University School of Medicine Inha University Hospital Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University School of Medicine Inha University Hospital Department of Pathology
주영채 ( Chu Young-Chae )
Inha University School of Medicine Inha University Hospital Department of Pathology
김영모 ( Kim Young-Mo )
Inha University School of Medicine Inha University Hospital Department of Otorhinolaryngology-Head and Neck Surgery
박인서 ( Park In-Suh )
Inha University School of Medicine Inha University Hospital Department of Pathology
임주한 ( Lim Joo-Han )
Inha University School of Medicine Inha University Hospital Department of Internal Medicine
KMID : 0357920140480040263
Abstract
Background: Epithelial mesenchymal transition (EMT) has an important role in invasion and metastasis of tumor cells. The purpose of this study was to evaluate the roles of EMT-associated proteins on progression and metastasis as a prognostic/predictive factor in curatively-resected (R0) head and neck squamous cell carcinoma (HNSCC).
Methods: A total of 118 patients who received curative surgery for HNSCC at Inha University Hospital between January 1996 and December 2011 were included. We used protein immunohistochemistry to evaluate the expression of E-cadherin, vimentin, and EZH2 on tissue microarrays. Also, we reviewed all medical records and analyzed the relationship between the expression of EMT-associated proteins and prognosis.
Results: The E-cadherin-negative group showed more moderate/poor differentiation of cancer cell type than the higher E-cadherin?expressing group (p=.016) and high EZH2 expression was significantly correlated with nodal metastasis (p=.012). Our results demonstrate a significant association between high expression of EZH2 and vimentin and presence of distant progression (p=.026). However, expression of E-cadherin, vimentin, and EZH2 was not significantly associated with overall survival.
Conclusions: These findings suggest that an EMT-associated protein expression profile is correlated with aggressiveness of disease and prognosis, and could be a useful marker for determination of additional treatment in curatively-resected HNSCC patients.
키워드
Carcinoma; squamous cell of head and neck; Cadherins; Vimentin; Enhancer of zeste homolog 2
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