Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low- Grade Sarcoma: An Immunohistochemical Study
손현진, 백태화, 이승윤, 김주헌, 강동욱, 이혜경, 박미자,
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손현진 ( Son Hyun-Jin )
Eulji University School of Medicine Department of Pathology
백태화 ( Baek Tae-Hwa )
Eulji University School of Medicine Department of Pathology
이승윤 ( Lee Seung-Yun )
Eulji University School of Medicine Department of Pathology
김주헌 ( Kim Joo-Heon )
Eulji University School of Medicine Department of Pathology
강동욱 ( Kang Dong-Wook )
Eulji University School of Medicine Department of Pathology
이혜경 ( Lee Hye-Kyung )
Eulji University School of Medicine Department of Pathology
박미자 ( Park Mee-Ja )
Eulji University School of Medicine Department of Pathology
KMID : 0357920140480040270
Abstract
Background: Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.
Methods: We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.
Results: The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.
Conclusions: This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.
키워드
Nodular fasciitis; Sarcoma; Cyclooxygenase 2; HuR; Immunohistochemistry
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